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Produkte > BioPrime Antikörper

Art.-Nr.


LU305: Lung carcinoma Cluster 2 (MOC-31)



Preis: 160 € / 3 ml

Monoclonal Antibodies

Herkunft:Mouse
 
Isotyp:IgG1
 
Klon:MOC-31
 
Form:ready to use
 
Menge:3 ml
 
Arbeitskonzentration:neat
 
Präsentation:Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**. The volume is sufficient for at least 30 immunohistochemical tests (100 µl working solution / test). Use appropriate antibody diluent e.g. BIOLOGO Art. No. PU002 if required.
 
Immunogen:Preparation of a SCLC-derived cell line
 
Spezifität:Cluster 2 membrane antigen 40 kDa
 
Artspezifität:Human
 
Allgemeines:Lung cancer is a heterogeneous disease which may be characterized by five histopathological criteria. A distinction is drawn between squamous epithelial carcinoma, adenocarcinoma, large cell carcinoma, adenosquamous carcinoma and small cell lung carcinoma (SCLC). The first four in this line are cited as non-SCLC in literature. A number of antibodies have been used for the characterization and clustering of lung carcinoma during the 1. International Workshop on Small Cell Lung Cancer Antigens, London 1987.
 
Spezielle Eigenschaften:MOC-31 antibody is reactive with all lung carcinoma and most epithelia. It doesn't react with mesothelia and for this reason it is especially useful for the detection of carcinoma cells in ascites or pleural effusates and for the differential diagnosis of mesothelioma.
 
Positivkontrolle:Lung carcinoma
 
Vorbehandlung:Heat pre-treatment of formalin-fixed tissue with Unmasking Fluid C or G (Art. No. DE000 and DE007)
 
Anwendung:IHC(P)
 
Inkubationszeit:60 min at RT
 
Sekundärreagenzien:We recommend the use of BIOLOGO's Universal Staining System DAB (Art. No. DA005) or AEC (Art.-No. AE005), if higher sensitivity is required VECTASTAIN Elite ABC (Art. No. PK-6102) or ABC AP (Art. No. AK-5002) systems are applicable.
 
Lagerung:2-8°C
 

Literatur:
1. Berendsen H.H., et al. (1988) Detection of small cell lung cancer metastases in bone marrow aspirates using monoclonal antibodies directed against neuroendocrine differentiation antigen. J. Clin. Pathol. 14; 273-276

2. Ordóñez NG (1998) Value of the MOC-31 monoclonal antibody in differentiating epithelial pleural mesothelioma from lung adenocarcinoma. Hum Pathol. 1998 Feb;29(2):166-9.


3. Huang YG, Xu YY, Zheng ZH (2002) Significance of MOC-31 and CD56 detection in human lung carcinoma tissues. Ai Zheng. 2002 Nov;21(11):1235-7.[Article in Chinese].


4. Pai RK, West RB. (2009) MOC-31 exhibits superior reactivity compared with Ber-EP4 in invasive lobular and ductal carcinoma of the breast: a tissue microarray study. Appl Immunohistochem Mol Morphol. 2009 May;17(3):202-6.




Hinweise
*BIOLOGO's antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!

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